Abstract
The objective of present study is to evaluate the cardioprotective activity of Naringin against doxorubicin induced cardiomyopathy in male albino rats. Naringin is a flavanone glycoside has the ability to act against oxidative stress, and increase the levels of enzymes that counteract oxidative stress. Rats were divided into 4 groups of 6 animals in each and treated for 8 weeks with naringin against doxorubicin. Doxorubicin was administered i.p. for a cumulative dose of 24 mg/kg body weight over a period of eight weeks in eight consecutive doses. Naringin 100 & 200 mg/kg dose were started one week prior to Doxorubicin, and was continued with daily dose of 100 & 200 mg/kg body weight. Serum samples and heart homogenates were used to estimate Troponin I, Creatine Kinase, LDH, SGPT, SGOT, LDH, SOD, CAT, GSH, MDA, Iron and Calcium. The results were expressed as the mean ± S.E.M. The results obtained were analyzed using One way ANOVA followed by Tukeys post hoc test. Doxorubicin treated rats showed significant increase in serum and oxidative biomarkers indicating cardiomyopathy. Naringin treatment significantly decreased serum biomarkers levels Troponin I, Creatine Kinase, SGPT, SGOT, Iron and Calcium. It also decreased oxidative biomarkers LDH and MDA and whereas it increased SOD and CAT levels. In conclusion, the present study indicates that Naringin offered dose dependent significant cardiac protection and healing effect against doxorubicin induced Cardiomyopathy in rats. The possible mechanisms involved in the cardioprotection of Naringin might be antioxidant and free radical scavenging properties.
