Abstract

In the present work, fast dissolving tablets of Losartan Potassium were prepared by mass extrusion method. As precision of dosing and patient's compliance become important prerequisites for a long-term treatment, there is a need to develop a formulation for Losartan Potassium which overcomes the problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient’s acceptability. Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of Losartan Potassium which offers a new range of products having desired characteristics and intended benefits. Three super-disintegrants viz., sodium starch glycolate (SSG), Avicel pH(MCC) and L-HPC were used in different ratios. The prepared batches of tablets were evaluated for different parameters. In all the formulations, in vitro disintegration, in vitro dispersion and wetting time found less than 30 seconds. This indicates rapid disintegration. Water absorption ratio showed good absorptivity in all formulations. In vitro release studies revealed that 96% of drug releases from SSG, MCC (90%), and L-HPC (85%) for all the formulations were within 15 min. Stability studies were conducted for formulations F3, F6 and F9 at 25⁰C/60% RH and 40⁰C/75% RH for 30 days.  Not much variation or change was observed in any parameters throughout the study period. Losartan Potassium mouth dissolving tablets formulated by using sodium starch glycolate as superdisintegrant have shown good in vitro disintegration time (8.00sec), in vitro dispersion time (14.33sec), compared to other superdisintegrants. Thus it can be better used as fast dissolving tablet to increase patients acceptability.