Abstract A new, simple, rapid and novel spectrophotometric method has been developed for estimation of Ramipril (RAM) and Hydrochlorothiazide (HCT) in bulk and combined pharmaceutical formulations using absorbance correction method (ACM). λmax of RAM was found at 209nm and HCT was at270nm respectively. This method involved measurement of absorbance at two wavelengths of RAM & HCT i.e., 209 nm and 270 nm for RAM and 270nm & 209nm for HCT. The combination is also estimated by ACM. It showed linearity of both the drugs at two wave lengths. Calibration curve was constructed at 209nm & 270nm for RAM and 270nm & 209nm for HCT respectively. Beer’s law obeyed in concentration range of 0.1‐ 0.5 μg/ mL for RAM and 0.25‐ 1.25 μg/ mL for HCT respectively by the method. These methods were validated for precision, reproducibility, linearity and accuracy as per ICH guidelines. The proposed methods are recommended for routine analysis since they are rapid, simple, accurate, cost effective and also sensitive and specific. It involves neither heating nor use of any organic solvent for separation of the combination. This study thus exploits the possibility for determining Pharmacokinetic data of the combined formulation which may be required in pre-clinical and clinical study in near future
