Abstract

Efficient synthesis of novel substituted quinolone derivatives with substituted amino-thiophene at third position of quinoline and morpholine at second position. The new compounds (1a-d) synthesized from condensation of 2-morpholinoquinoline-3-carbaldehyde with 2-Amino-5-methylthiophene-3-carbonitrile by refluxing in alcoholic solvent to form corresponding Schiff’s bases followed by imine(C=N) bond reduction in to corresponding amine using sodium borohydride in alcoholic solvent at elevated temperature. The newly synthesized compounds (1a-d) were isolated in pure form by means of crystalization & characterized using Mass Spectrometry, IR, and 1H-NMR, 13C-NMR spectroscopy and shows encouraging  results of  activity study in antibacterial and antifungal area