Abstract
Series of tris(heterocycle) bearing isoxazoline ring in combination with imidazole ring has been synthesized via 1,3-dipolar cycloaddition reactions of N-(substituted)methyl-imidazole nitrile oxides with different dipolarophiles. All the newly synthesized compounds were characterized by infrared spectroscopy (IR), 1H and 13C nuclear magnetic resonance (NMR) and elemental analysis. Compounds were screened for their anti-inflammatory and analgesic activity. Compounds 4d, 4e and 4f were discovered as significant anti-inflammatory and analgesic agents showing activity comparable to that of standard drugs.
