Abstract
Background: Hypertension (HTN) with coronary heart disease (CHD) is one of the leading causes of death in worldwide. There are many studies conducted in hypertension with CHD. The aim and objectives of the present study is to analysis the different patterns and identifying the various parameters of DRPs as well as categorization of DRPs in the hypertensive with CHD who visits at a tertiary care teaching hospital.Method: The observational prospective study. The present study was conducted in hypertensive subjects with Coronary heart diseases Outpatient and Inpatient of department of medicine at a tertiary care teaching hospital located at Chidambaram, Tamil Nadu and South India. Study was conducted for two months (August and September 2013). The identification and categorization of DRPs was according to the Pharmaceutical Network Care Europe (PCNE) tool version 5.01. Results: 50 prescriptions were identified for this study. Among 35 prescriptions were analyzed clinical DRPs and 15 prescriptions were analyzed of technical DRPs. Among 35 prescriptions 75 clinical DRPs was detected with frequently identified clinical DRPs (P1 – P6) were (P1) adverse drug reactions 9(18%), (P2) drug choice problem 11(22%), (P3) dosing Problem 5(10%), (P4) drug use problem 11(22%), (P5) Potential drug–drug interactions 8(16%) were detected. Also (P6) ‘others’ were insufficient awareness of health and diseases 31(62%) and technical DRPs were identified such as “missing dose” 4(8%) and “unreadable prescription” 4(8%) and “missing diagnose” in the prescription 7(14%). The identification and categorization of causes of DRPs were observed that, 75 DRPs were detected with 92 causes of DRPs on hypertension with CHD. In that, (C2) ‘Drug use process’ 28(56%), (C3) Subject unawareness information for drug treatment’ 21(42%) cases, and then followed by (C4) ‘Subject/Psychological’ 43(86%) cases of high frequency of causes of DRPs presents in this study.Conclusion: The Pharmacist was identified 75 number of clinical DRP and 15 number of technical DRP presents in this study using PCNE tools and also elderly subjects were specially observed and found that there is no significant difference and categorized into six domains, and causes of DRP in hypertensive subjects associated with CHD at tertiary care teaching hospital.
