Abstract
The present research work is to formulate fast disintegrating tablets of an Anti mucolytic drug, Ambroxol hydrochloride with sufficient mechanical integrity and achieving faster disintegrating with patient convenience using natural super disintegrants such as guar gum and karaya gum by Direct compression technique. Preformulation studies such as Angle of repose, bulk density, tapped density and carr’s compressibility index for all six formulations were done. All F6 formulations were compressed after preformulation studies. The compressed tablets were evaluated for physical characteristics such as weight variation, Friability, Hardness, Disintegration test and In Vitro dissolution studies. All the formulations shows compliance with Pharmacoepial standards. In vitro dissolution studies were done for all formulation for 30 mins in USP type II (paddle type) apparatus by using phosphate buffer of pH6.8 shows 98.91%.The release kinetics were analyzed by using zero order, First order, Higuchi’s plot and Korsemeyer’s equation for the optimized formulation.The regression coefficient is obtained i.e., R2 = 0.998 with n value of 0.45 following Fickian transport. No significant difference were seen in formulation F3 by doing stability studies.The results suggest that developed Fast disintegrating tablets of Ambroxol Hydrochloride shows immediate release leading to improve Patient convenience according Disintegration test and In Vitro dissolution studies.By comparing the two natural polymers in all six formulations it is concluded that guar gum of 18 mg is showing highest drug release than the karaya gum of 18 mg according to In Vitro dissolution studies.
