Abstract

Niosomes are novel/particulate drug delivery that promotes formations of vesicles by hydrating the mixture of cholesterol and non-ionic surfactants. Niosomes are vesicles composed of non-ionic surfactants, which are biodegradable, relatively nontoxic, more stable and inexpensive, an alternative and superior to liposome will be acts as a target drug delivery system/CDDS. Niosomes have become popular in the field of topical drug delivery due to their outstanding characteristics like enhancing the penetration of drugs, providing a sustained pattern of drug release, increasing drug stability and ability to carry both hydrophilic and lipophilic drugs. This article reviews the current deepening and widening of interest in research activities in such a way that to improve entrapment efficiency can be expected to prolong the duration of the drug in systemic circulation. They possess an infrastructure consisting of hydrophilic, amphiphilic and lipophilic moieties together and as a result can accommodate drug molecules with a wide range of solubilities. The present article highlights the various factors which governs the formation of niosomes.