ABSTRACT The latex is widely used in cosmetics, pharmaceuticals and food industry as in paper, textile and petroleum industries also. The present study was carried out to assess the potential antimicrobial activity of methanolic, ethanolic and chloroform extracts of fruit latex of Artocarpus communis against different pathogenic bacteria and fungus. All three extracts were found to show good to moderated activity against bacteria namely Gram +ve (Bacillus cereus, Bacillus subtilis and Staphylococcus aureus) and Gram –ve (Escherichia coli and Pseudomonas aeurignosa) and fungal stains namely Aspergillus flavus, Aspergillus niger, Candida albicans and Saccharomyces cerevisiae. In methanolic extract major activity was perceived on bacteria Bacillus subtilis and among fungi Aspergillus niger. In ethanolic extract maximum activity perceived on bacteria Escherichia coli and amongst fungi Aspergillus flavus. In chloroform extract determined activity was observed on bacteria Staphylococcus aureus and between fungus Candida albicans. Maximum activity was observed on bacterial strains compared with fungal strains. In all three extracts Minimum inhibitory concentrations were in the range of 12.5-25 mg/ml. In addition, quantitative phytochemical estimations of assured active compounds like Total phenolics, flavonoids, tannins, proteins, carbohydrates, glycosides, and alkaloids were found to be in considerable quantities.