Abstract
Purpose:The main Objective of the present investigation was to explore the potential of cremophore-EL, Polysorbate-80 and Ethanol as co-solvent for use in formulation of Self Nano Emulsifying Drug delivery system loaded docetaxel. Method: Seven Different formulations of SNEDDS were prepared by using different oils, surfactants and co-surfactants such as Capmul,transcutol-HP as oil and Cremophore EL, Polysorbate 80 as surfactant, PEG-400,glycerol,ethanol as co-surfactants/solvents in different concentrations. Ternary phase diagrams were plotted to identify the efficient self nano emulsifying region. Seven formulations (F1, F2, F3, F4, F5, F6 and F7) were prepared with optimized concentrations of ingredients. Comparative account of these formulations on the basis of the parameters like droplet size and dilution study was prepared. From the present study, it was investigated that among the seven formulations.Results: SNEDDS formulated with F7 was clear, of smallest vesicle size, exhibiting no change on dilution even after 8 hours. Thus, cremophore-EL, Polysorbate 80 has the excellent surfactant property to formulate SNEDDS.*SNEDDS- Self Nano Emulsifying Drug Delivery System.
