Abstract
The purpose of this study is to prepare and characterize immediate release pellets and tablets of irbesartan as it is a class II drug according to Biopharmaceutical Classification System. Irbesartan pellets were prepared by solution layering technology in which PVP K – 30 as a binder and alcohol as solvent were used. Tablets were prepared by both wet granulation and direct compression method. In order to obtain acceptable product, several trials were conducted and effect of fillers and disintegrants were explored. Physical properties of granules such as Bulk density, Tapped density, Hausner’s Ratio, Carr’s index, Angle of repose, Weight variation, Hardness, Disintegration time, Friability index and in – vitro Dissolution studies were conducted. From the studies and data obtained, best formulation was found to be F – 13 which contains PEG 6000 (5%W/V solution as binder), Sodium starch glycolate (disintegrant) and lactose (diluent) along with magnesium stearate and talc as lubricant and glidant respectively. As 80 % of irbesartan was released from formulation F -13 and pellets within 10 min, it states that PEG 6000 increases the dissolution rate of a poorly soluble drug in combination with super disintegrants. Hence they are likely to be better bioavailable though they belongs to class II drugs.
