Abstract
The aim of present investigation is the design and evaluation of controlled release matrix tablets for Selective β1 receptor blocker of Metoprolol succinate. Optimization of formulations of matrix tablet was done by 23 factorial design. Formulation of controlled release matrix tablets of Metoprolol succinate was carried out by wet granulation method by using different polymers like HPMC K4M, Guar gum and Sodium Carboxy Methyl Cellulose. The micromeritic properties of prepared granules such as Bulk density, Tapped density, Angle of repose, Compressibility index, Hausner’s ratio indicated the good flow property of prepared granules. The physicochemical characterization of prepared matrix tablets such as Thickness, Weight variation, Hardness, Friability and Drug content were evaluated. Almost satisfactory results were obtained in all the formulations. The compressed tablets were subjected for in-vitro drug release, kinetic studies and stability studies. The formulations MT4 (95 mg) and MT14 (95 mg) sustained the action upto 24 hrs. Drug diffusion from matrix tablets showed apparently zero order kinetics and release mechanism was diffusion controlled. The best formulations subjected to stability studies indicated that the tablets did not show any characteristic changes. It was concluded that the developed controlled release matrix tablet using HPMC K4M and Guar Gum shows satisfactory release retarding of Metoprolol succinate and its improved efficacy can perform therapeutically better than a conventional tablet.
