Abstract
An attempt has been made to formulate solid lipid nanoparticles (SLNs) for the drug Thiocolchicoside, which is a muscle relaxant with anti-inflammatory and analgesic effects. Controlled release of SLNs of the drug thiocolchicoside were prepared by the solvent evaporation method. Optimisation was done using a Box-Behnken design which was constructed using the parameters solid lipid (X1), surfactant (X2), and drug/lipid ratio (X3) level as independent factors based on the preliminary experimental data. The formulations were evaluated on various parameters such as size of the nanoparticles, entrapment efficiency of thiocolchicoside and its release behavious from the formulation. Optimized solid lipid nanoparticles were found to have a particle size of 542 nm and EE% of 85 %.FTIR spectra and of thiocolchicoside, lipids, indicate that there is no chemical interaction between them and confirmed the stability of the drug. SEM study confirmed the non-spherical shape of Solid lipid nanoparticles. The solid state of the drug in the Solid lipid nanoparticles and lipid modification was characterized. The in vivo characterisation studied by rat paw edema technique suggested effective anti-inflammatory response. Due to enhanced bioavailability, these thiocolchicoside- Solid lipid nanoparticles can be considered to be promising vehicles for drug delivery.
