Abstract

Clotrimazole is an Anti-fungal drug and used to  treat Antifungal diseases. Clotrimazole is characterised by its poor water solubility and low bioavailability. The main objective of present study was to prepare Clotrimazole gels by hydrotropic phenomenon using Sodium salicylate, Sodium Benzoate as hydrotropic salt and by using corn and potato starch. Clotrimazole formulation was prepared by Hydrotropic technique and Hydrotropic starch gel was formed and characterize systematically for various physico-chemical parameters like drug content estimation, pH, tube extrudability, spreadability, IR spectral analysis for any drug excipients interactions etc. All the prepared formulations were subjected to in-vitro drug release studies by diffusion method for six hours In 100 ml phosphate buffer (pH 7.4) and compared with marketed formulation and stability study of the best formulation was carried out for a period of 90 days at 28 ±2 ^oC and 5± ^oC. The hydrotropic starch gel was found to be in an acceptable range. The pH of all the formulation were found between 6-7.5 pH. Drug content was found within  range 98.5%-100.5%.The percent drug release of hydrotropically starch gel among all the formulation the percent drug release of W8s-c-d was found to be best 85 %.where as the marketed was found to be 46%.The  viscosity (cp) value of W8s-c-d was found to be 6960. Spreadability plays an important role in patient compliance and help in uniform application of gel to the skin as gels should spread easily , the formulation was found to have better spreadability. Drug and polymer interaction study done by FTIR and revealed that there is no interaction.and concluded that W8s-c-d formulation was the best formulation