Abstract

The present study was taken up to understand the influence of selected antiarrhythmic drug (disopyramide) on the pharmacodynamics and pharmacokinetics of gliclazide in rabbits. This study is planned to establish the safety of the drug combinations. Studies in normal rabbit conducted with oral doses of disopyramide, gliclazide and their combination with appropriate washout periods in between treatments. Blood samples were analyzed for blood glucose by GOD/POD method, serum gliclazide levels by HPLC method. In combination antiarrhythmic drug (disopyramide) improved the activity of gliclazide. The findings suggest that the interaction observed was pharmacokinetic and pharmacodynamic in rabbits.