Abstract
Abstract
A sufficient and steady release of drug is important for the prepared oral solid dosage forms of pharmaceutical products. Delivering the drug at appropriate site is also essential. Hence pharmaceutical products must be designed to fulfill these requirements. In the present investigation both effervescent and non-effervescent floating drug delivery systems are prepared. Effervescent type oral floating alginate gel beads of Famotidine are prepared using gas generating agent sodium bicarbonate. Corn oil is utilized as a dispersed phase to generate a uniform emulsion to create multiple tiny chambers in the alginate matrix for better buoyancy. The effect of different concentrations of sodium alginate, calcium chloride and Famotidine is studied and their Morphological analysis, Buoyancy, Encapsulation efficiency and In-vitro drug release behavior are carried out. For the non-effervescent type, Famotidine is initially dispersed in alginate solution containing corn oil. A controlled release polymer along with solubility enhancers like PEG 4000 or PEG 6000 is added. Morphological evaluation, Buoyancy study and spectral interpretation studies are performed. It is concluded that Famotidine release from effervescent beads occurred in a “burst” within the first 5-15 min, due to rapid water ingress and creation of aqueous channels. For the non-effervescent type, the presence of solubility enhancers like PEGs resulted in fickian diffusion with erosion type of release while the presence of controlled release polymer resulted in a Higuchi type of drug release.
