Abstract
Proteomic study of human body fluid (saliva and serum) holds assure as a non-invasive method to identify biomarkers for human oral cancer. The evolving of novel technologies allows researchers to aid the inclusive analyses of proteomes in cancer. The protein expression pattern of tumors cells measure by proteomics technologies that provide opportunities to discover potentially new biomarkers for the early detection and diagnosis of oral cancer. Different proteomic tools such as 2DPAGE, 2D-DIGE,MALDI, SELDI-TOF-MS LC-MS/MS technology, protein arrays, iTRAQ, ICAT and MudPIT have been used for discrepancy analysis of various biological samples, including cell lysates, Saliva, serum, plasma and tumors tissue to better understand the molecular foundation of cancer pathogenesis and the validation and characterization of disease-associated proteins. This review covers a selection of advances in the dominion of proteomics and its promise for oral cancer biomarker discovery. It also introduces sample preparation and discusses current challenges that need to be defeat and the efforts of the Early Detection of oral cancer and promoting biomarker discovery for conversion at the clinical level.
