Abstract

The present research work is directed towards the study of hepatoprotective activities of herbal formulation against paracetamol-induced hepatotoxicity in rats. The study was designed to evaluate the hepatoprotective activity of herbal formulation in acute experimental liver injury induced by paracetamol (750mg/kg) in Wistar albino rats. The effect of formulation was also studied on serum glutamate oxalate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), total bilirubin, and total protein.   The histological study exhibited reduced signs of paracetamol-induced hepatotoxicity. The hepatoprotective activity of formulation (100mg/kg and 200mg/kg) was also substantiated by significant (p<0.05) decrease in levels of SGOT, SGPT, SALP, and Total bilirubin. The effects of formulation were comparable to that of standard drug, Silymarin. From the study, it can be concluded that the herbal formulation has hepatoprotective activity.