Abstract
The aim of the present study was to determine the comparative mucoadhesive strength , mucoadhesive force and mucoadhesive retention time of some natural polymerts by simple invitro method. Various natural polymers were selected in the current study. The tablets were prepared by wet granulation method and the following evaluation methods were used such as swelling index, mucoadhesive strength, mucoadhesive force, ex-vivo mucoadhesive time and in-vitro mucoadhesive retention time was determined. And all these in-vitro evaluations were done by using goat intestinal mucous memberane. The study reveals that the ascending order of natural polymers for formulating a gastro retentive mucoadhesive system was found to be gum Arabic(1.53) < neem gum(1.55) < locust bean gum(1.60) < tragacanth(1.64) < chitosan(1.71) < guar gum(1.82) < xanthan gum(1.87) < karaya gum(1.92) < carbopal 934(2.27).
