Abstract
The aim of this study was to prepare and characterize lornoxicam nanosuspensions to enhance the dissolution rate of this drug. Nanosuspensions were prepared by the precipitation–ultrasonication method.. The particle size and zeta potential of nanospray dried powder were 213nm and −20mV, respectively. The morphology of nanocrystals was found to be spherical in shape by scanning electron microscopy (SEM) observation. The X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC) analysis indicated that there was no substantial crystalline change in the nanocrystals compared with pure drug. The in vitro dissolution rate of lornoxicam was significantly increased by reducing the particle size. . The amorphous LOR nanoparticles showed dramatic improvement in rate as well as extent of in-vitro drug dissolution. The improvement can be attributed to amorphization and surface area, reduced particle size and decreased diffusion layer thickness. Spray drying process produced dry nanosuspension with high stability compared to liquid formulation.
