Abstract
A series of ester derivatives of (6-chloro-3-oxo-2,3-dihydro-1H-inden-l-yl)acetic acid were synthesized and screened for their analgesic and anti-inflammatory activities. These were designed to serve as possible potential nonsteroidal anti-inflammatory agents free from gastrointestinal toxicity and sulphur sensitivity. The synthesized compounds exhibited useful analgesic activity but low anti-inflammatory activity. Few selected compounds were also screened for their antipyretic and ulcerogenic potential. The compounds showed no ulcer formation at the dose level of 100 mg/kg p.o. Aspirin was used as the standard nonsteroidal anti-inflammatory agent. Experimental results indicate that compound 5d holds promise to serve as a novel lead for designing better (less toxic) analgesic antipyretics.
