Abstract
Risperidone, a benzisoxazole derivative, is an atypical antipsychotic drug with high affinity for 5-hydrotryptamine (5-HT) and dopamine D2 receptors. It is used primarily in the management of schizophrenia, inappropriate behaviour in severe dementia and manic episodes associated with bipolar I disorder. But this drug has bitter taste which may leads to patient’s non compliance. Ion exchange resins are water–insoluble, cross–linked polymers containing salt forming groups in repeating positions on the polymer chain.1 It can be used in the drug formulations to stabilize the sensitive components, sustain release of drug, disintegrate tablets and mask taste. Kyron T-104 is Ion exchange resin. Aim of this research work was to develop mouth dissolving tablet that disintegrates rapidly in mouth by using tasteless complex of Risperidone and Kyron T-104. Effect of different parameters such as swelling time, resin activation, drug resin ratio as well as stirring time was optimized by taste and percentage drug loading. Formulated DRC (Drug Resin Complex) was characterized by infrared spectroscopy. Tablets were formulated by direct compression with Kyron T-314 as super disintegrants. In these batches optimum hardness was achieved but disintegration time was found to be 20 second. Tablets formulated with 10% Kyron T-314 showed comparatively low disintegration time (20 sec), and friability (0.60 %) than the other batches. In present study we optimized the conditions required for maximum drug loading of Risperidone with Kyron T-104. Among different superdisintergants was found suitable with drug-resin complex to get the low disintegration time and friability of tablets.
