Abstract

Assessment of liver can be made by estimating the activities of ASAT, ALAT, ALP and LDH, which are enzymes originally present in higher concentration in cytoplasm. When there is hepatopathy, these enzymes leak into the blood stream in conformity with the extent of liver damage. Many toxins target the liver and cause hepatotoxic effects that can be observed through some biochemical parameters. Impairment of the liver generally occurs from excessive exposure to xenobiotics, alcohol, chemotherapeutic agents, virus and protozoan infections. Depending upon the severity of toxicant insult, hepatic cell injury can lead from acute to chronic hepatitis, which if left untreated can result in cirrhosis or malignant lesions. In this paper we study of the effect of selected drugs against each toxicant by estimating the biochemical parameters using hepatocytes.