Abstract
Metoprolol tartrate is effective β-blocker which is having antianginal properties and used in the treatment of myocardial infarction. Oral bioavailability of metoprolol tartrate is around 40%. In present work an attempt has been made to prepare fast dissolving tablets of metoprolol tartrate to enhance the dissolution rate. Sublimation method . The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. In all the formulations, friability is less than 1%, indicated that tablets had a good mechanical resistance. Drug content was found to be in the range of 98 to 102%, which is within acceptable limits. In sublimation method, camphor is used as subliming agent. All the tablets of metoprolol tartrate were subjected to weight variation, hardness, friability, in vitro dispersion, drug polymer interaction, drug content uniformity, and in vitro drug release The drug release from tablets of metoprolol tartrate prepared by sublimation methods were found to be S1 showed 98.20% drug release within 10 minute. It is concluded that Metoprolol Tartrate mouth dissolving tablets could be prepared using sublimation technique with improved bioavailability and rapid onset of action.
