Abstract
The anti-ulcer effect of aqueous extract of Aerva lanata stem was tested against ulcers induced by ethanol, pyloric ligation, indomethacin and cysteamine in wistar albino rats. The anti-ulcer activity was assessed by determining and comparing the ulcer index in the test group (250,500 mg/kg) with that of the control group and omeprazole 20mg/kg was used as a reference standard. Aerva lanata significantly decreased free-acidity, total-acidity, ulcer index and increased the pH in pylorus ligated model where as ulcer index decreased in ethanol, indomethacin and cysteamine induced models. One of the more significant findings to emerge from this study is that aqueous extract of Aerva lanata stem possess antiulcer properties in a dose dependent manner which could be either due to cytoprotective action, anti secretory or anti oxidant mechanism of the drug. The antiulcer properties of the extract may be attributed to the presence of phyto chemicals like flavonoids, alkaloids and tannins present in the plant extract with various biological activitiesDepartment Of Pharmaceutical chemistry: Mallareddy College of Pharmacy, Medchal.
