Abstract

Telmisartan is a well-known and widely used anti-hypertensive agent and it belongs to bio-pharmaceutical classification system (BCS) class II drug with low solubility and high permeability. The present study was aimed to enhance the solubility of Telmisartan by solid-dispersion techniques (physical mixing and solvent evaporation methods) using carriers like Micro crystalline cellulose, Sodium Starch Glycolate, Cross-povidone and Cross-caramellose sodium. The prepared formulations were characterized for percentage practical yield, drug content and in-vitro drug release studies. Amongst the formulations prepared (F1-F5), F5 formulation consisting of Telmisartan and Crospovidone in the ratio 1:4was considered as optimized formulation in which percentage drug release was found to be 98.82% within 60 minutes in comparison with that of pure drug dissolution of only 65.46% within 60 minutes. Solubility and drug release rate of Telmisartan was enhanced in all the formulations (F1-F5) by this technique. The order of enhancement of the drug release rate with various carriers was found to be CP>SSG > CCS > MCC.