Abstract
Radioprotective agents are the compounds which are used for the protection of normal tissues during accidental and therapeutical exposure to ionizing radiation. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a pyrazolone derivative known for its radioprotective and neuroprotective efficacy. The present work describes the evaluation of radioprotective efficacy of edaravone derivative with trifluoromethyl moiety, 3-methyl-1- (4-(trifluoromethyl)phenyl) -1,2-dihydropyrazol-5-one (MTMPP). The in vitro antioxidant activities namely DPPH radical scavenging, nitric oxide radical scavenging and reducing power activity assay of MTMPP showed a comparable activities with that of standard edaravone. The MTMPP pretreated flies on 3Gy electron beam irradiation exhibited a considerable radioprotective ability towards radiation induced oxidative stress damage by diminishing lipid peroxidation, elevating glutathione level and by restoring the activities of antioxidant enzymes SOD and CAT to near basal level.
