Abstract
Most of the active pharmaceutical ingredients (APIs) under development are poorly water soluble and have poor bioavailability. Nanotechnology is an approach to overcome the challenges of conventional drug delivery systems. The solubility, in vivo stability, intestinal absorption, route of administration, targeting, effectiveness and side effects are the challenges that push the researchers toward exploring a new drug delivery. Nanoparticles made from solid lipid are alternative novel colloidal drug carrier to alter and improve the pharmacokinetic and pharmacodynamics properties of drug molecules. The present review focused on increasing awareness about nanotechnological field in drug delivery with the emergence of several approaches based on solid lipid like Solid lipid nanoparticles, Nanostructured lipid carriers, Lipid drug conjugates, Polymer lipid hybrid nanoparticles for improving medical therapeutics. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and have attracted wide attention of researchers.
