Abstract
The aim of the present study was to develop and optimize Self nanoemulsifying drug delivery system (SNEDDS) of glimepiride and convert to solid Self nanoemulsifying drug delivery system (S-SNEDDS). For screening purpose the solubility of glimepiride in various oils (Lipids), surfactants and co-surfactants was determined to select a suitable combination of these ingredients. Emulsification efficiency was determined and also pseudo-ternary phase diagrams were constructed. From the results of screening, four formulation variables were selected X1 Caproyl®90 (Lipid), X2 Cremophor®EL (Surfactant), X3 Capmul® MCM (Lipid) and X4 Simulsol® (Co-surfactant) and D-optimal mixture experimental design was applied to optimize SNEDDS of glimepiride. Eleven formulations were prepared and evaluated for drug release, % transmittance and globule size. The optimal formulation F9 was composed of glimepiride (2%), Caproyl®90 (20.8%), Capmul® MCM (15.6%w/w), Cremophor® EL (49.5%), Simulsol® 1292 (14% w/w) which was converted to S-SNEDDS using spray drying in presence of Aerosil® 200 Pharma. The spray dried particles of S-SNEDDS of glimepiride showed good flow properties. The drug content of S-SNEDDS, drug release, % transmittance and globule size were found to be 96.00%, 95.00%, 98.00% and 22.4 nm respectively. The S-SNEDDS of glimepiride showed drug release 99.03 % over 79 % drug releases from marketed product in 60 minutes. From the result s obtained S-SNEDDS could be promising to improve oral efficacy of glimepiride.
