Abstract
Nanoparticles have tremendous potential application in drug delivery system. Chitosan nanoparticles have received plenty of attention because of its non-toxicity, biocompatibility, biodegradability and controlled drug release. The objective of the present work was to evaluate the potential of chitosan-tripolyphosphate (TPP) nanoparticles as a carrier in the preparation of Terbinafine loaded nanoparticles in order to enhance the bioavailability of drug and to reduce dose frequency for preventing the side effects of the drug. Ionotropic gelation method was used for preparation of chitosan–TPP nanoparticles loaded with Terbinafine. The cross linking between TPP and chitosan was determined by FTIR studies. The particle size and zeta potential of nanoparticles were studied by dynamic light scattering (DLS) and zeta potential analyzer. Transmission Electron Microscopy (TEM) was used to determine the morphological characteristics of nanoparticles. The particle ranges from 139-200nm in size and have a positive zeta potential +13.6mV.Thevariations in the concentration of chitosan and TPP effects the size and zeta potential of particles. Also, the change in the chitosan and drug ratio changes the physicochemical properties of nanoparticles, particles size increases with the increase in the concentration of Terbinafine while the the zetapotential decreases. These nanoparticles have good encapsulation efficiency of 77.8% for Terbinafine. These studies suggest that chitosan can complex TPP to form terbinafine loaded nanoparticles and appears as a promising system in microbial treatment.
