Abstract

Cyanoacrylate and its derivatives attract the interesting investigative areas.
Cyanoacrylae molecule is generally described as macromolecule, which is
characterized by its extensive 3D structure that provides high degree of surface
functionality and versatility. The synthesis of cyanoacrylate polymer involves two
steps viz. double Michael addition step for formation of odd generation
cyanoarylate polymer and subsequent reduction of cyanoarylate polymer for
formation of even generation of cyanoacrylate polymer i.e. nitrile terminated
cyanoacrylate polymer. Of the two step, step number two i.e. reduction step is
highly crucial step in the scence that it involves many controlling parameters like
temperature, pressure, pH, and time of reaction. Considering the above fact, in the
present study an attempt was made to optimize the synthesis of cyanoacrylate
polymers. Further present study deals with gel formulation with cyanoacrylate
polymer and in vitro evaluation for the drug release. It has been found that
cyanoacrylate polymer helps to improve drug release by increasing binding of the
drug with receptor on cell membrane.