Abstract

Itraconazole is potent anti fungal drug of the triazole group with activity against histoplasmosis, blastomycosis, and onychomycosis.One of the major problems with itraconazole is that, it is practically insoluble in water, which results in poor bioavailability after oral administration. In this present study, Solid dispersion of itraconazole in Eudragit E 100, PVP K30, HPMC and PEG 6000 with different drug to carrier ratios were prepared by solvent evaporation method with aim of increasing dissolution rate and bioavailability of the drug. The new formulations were characterized in the solid state by FT-IR spectroscopy,SEM,X-ray powder diffraction in corresponding physical mixture revealed the changes in solid state during the formation of dispersion and justified the formation of high energy amorphous phase .Dissolution studies of itraconazole and its physical mixture in 0.1N Hcl containg 0.5% SLS showed negligible release.