Abstract
Quinapril hydrochloride is an ACE inhibitor used to treat high blood pressure and to help treat heart failure. The objective of the present investigation is to formulate bilayer tablets of Quinapril hydrochloride. It has biological half-life of 2 hours. An attempt was made in the direction of preparation and optimization of a combination of sustained release layer and immediate release layer in a single tablet. In sustained release layer polymers were used as retarding materials and in immediate release layer super disintegrant was used . The tablets were formulated using direct compression technology by employing polymers like Sodium alginate, Cekol 30000 and Kollidon SR in sustained release layer and crospovidone was used as super disintegrant along with other excipients. The drug-excipient compatible studies were performed by FTIR. The study revealed that there is no drug-excipient interaction. The prepared bilayered tablets were evaluated for various physicochemical parameters including in-vitro drug release studies of all formulations. Out of all formulations the one prepared with combination of sodium alginate and Kollidon SR has the release of drug over 12 hrs. The in-vitro release data was fitted to different kinetic models which showed highest regression for zero order kinetics with higuchi mechanism.
