Abstract
A simple stability-indicating high-performance liquid chromatographic method was developed and validated for the determination of Felodipine in tablet dosage forms. Reversed-phase chromatography was performed on Shimadzu Model CBM-20A/20 Alite, using a mixture of tetra butyl ammonium hydrogen sulphate and acetonitrile (18:82, v/v) as mobile phase with a flow rate of 1.2 mL/min. Detection was carried at 237 nm. Linearity was observed over the concentration range of 0.1–350 μg/mL (R2 = 0.9997) with regression equation y = 62606 x + 9590.9. Felodipine was subjected to stress conditions (acidic, alkaline, oxidation and thermal degradation) and validated as per ICH guidelines.
