Abstract
Three simple and sensitive first order derivative spectrophotometric methods (D1) were developed for the determination of Erlotinib hydrochloride in pharmaceutical formulations using 0.1 N HCl (Method A), acetate buffer (Method B) and phosphate buffer (Method C). Beer’s law was obeyed over concentration range 0.5-30 μg/mL for both Method A and B respectively and 1-30 μg/mL for Method C. The linear regression equations were found to be y = 0.0052x+0.0003, y = 0.0051x+0.0008 and y = 0.0038x+0.0016 for Method A, B and C respectively. The three methods were validated and no interference of the excipients was observed.
