Abstract
A simple stability-indicating high-performance liquid chromatographic method was developed and validated for the determination of Cabazitaxel in infusion forms. Reversed-phase chromatography was performed on Shimadzu Model CBM-20A/20 Alite, using a mixture of Phosphate buffer and Acetonitrile (30:70, v/v) as mobile phase with a flow rate of 1.0 mL/min. Detection was carried at 230 nm. Linearity was observed over the concentration range of 0.1–150 μg/mL (R2 = 0.9999) with regression equation y = 28290 x + 7032.3. Cabazitaxel was subjected to stress conditions (acidic, alkaline, oxidation, UV and thermal degradation) and validated as per ICH guidelines
