Abstract

In Indian traditional medicine, different parts of Jasminum grandiflorum Linn. (Oleaceae family) are valued highly for the treatment of Skin diseases, Ulcers, wounds, corns, ulcerative stomatitis, fixing loose teeth. In the present study, oral dose of 100 and 200 mg/kg/day of JGLE were studied for their protective effects in Gentamicin induced nephrotoxicity in wistar rats for 14days. The adult wistar rats were divided evenly into five groups. Groups I, II & III served as untreated, toxic controls  (Gentamicin 40mg/kg ) & Standard group (Vitamin E 250mg/kg) respectively while groups III&V were treated with 100 and 200 mg/kg/day of JGLE hr before each dose of the nephrotoxicant (Gentamicin 40mg/kg) for 14days. On the 15^th day, blood samples were collected by retro orbital puncture and estimated renal biochemical parameters. In toxic control (Gentamicin 40mg/kg) group, attenuated elevations in the serum creatinine, blood urea, uric acid, blood urea nitrogen, reduced levels of total proteins and Increased levels of urine parameters (urine creatinine, urine urea, urine uric acid and albumin) in dose related fashion. In group IV & V groups (pretreated with JGLE) attenuated significantly decreased levels of blood parameters (serum creatinine, blood urea, uric acid, blood urea nitrogen) and increased levels of total proteins and also decreased levels of urine parameters (urine creatinine, urine urea, urine uric acid and albumin) when compared to toxic control group. In Conclusion the results suggest that the JGLE shown the significant nephroprotective activity could be due to inherent antioxidant property and free radical scavenging principle contained in the extract. In near the future, JGLE could constitute a lead to discovery of a novel compound for the treatment of drug induced nephrotoxicity.