Abstract
The topicaland localized application are acceptable and preferred way to achieve therapeutic level of drugs to treat oculardisorders but the primitive ophthalmic solution, suspension, and ointment dosage form are no longer sufficient to combat variousocular diseases.Niosomes will offer a promising avenue to fulfill the need for an ophthalmic drug delivery system and acts as penetration enhancer that not only has the convenience of a drop but minimizing frequency of drug administration with patient compliance. In this present work thermoreversible niosomal gel formulation of Ganciclovir with factorial design 22 was prepared by ether injection method and evaluated for the entrapment efficiency, vesicle size, TEM, pH, viscosity, drug content&drug release study. The concentrations (12mg, 36mg) and type of surfactants (span 40, span 60) were selected as independent variables. It was found that span 60 with higher concentration had increased encapsulation efficiency and drug release 92.80±1.32 % up to 8 hrthan span 40 and pure drug gel. The present study explores the importance of niosomes as potential ocular drug delivery system, its formulation aspects and its characterization.Niosomal gel will serve as a better option for Ganciclovir ocular drug deliverysystem.
