Abstract
A series of Benzoyl arylamino 6, 7 – dihydro-5H-benzo[c]thiophen-4-one synthesized and evaluated for their anti-inflammatory activity. The target molecule were synthesized with the help of, 3-cyclohexadione, substituted aryl isothiocynates and phenacyl bromides. Synthesized compounds were further evaluated for their in-vitro anti-inflammatory action by Human Red Blood cell membrane stabilizing activity and protein denaturation, as well as for their anti-inflammatory activity in in-vivo model of acute inflammation the compounds were also evaluated for the antioxidant activity. Electron donating substituent on the 4 position of 3 phenylamino of 6,7-dihydro-5H-benzo[c]thiophen-4-one proved to be crucial for good activity. The compounds 4a-4d, 4h, 4i, and 4k-4l showed good activity in all the models. The benzo[c] thiophen-4-ones have proved to be a potential scaffold for anti-inflammatory activity. Results suggest the suitability of the designed molecular framework as a potential anti-inflammatory lead.
