Abstract
Diabetes mellitus has been major problem in developed and developing countries. The progression of disorder cause prolonged exposure of vascular tissues to hyperglycaemia resulting in long-term microvascular/ macrovascular complications in the health; and nephropathy is one of them. The present study was designed to evaluate the Effect of Omega-3 Fatty Acid on microalbuminurea and HbA1c level in patients with diabetic nephropathy. A randomized, open controlled clinical trial which includes 58 diabetic nephropathy patients (50men and 8 women) aged between 35–60 years who had diabetes for at least 5 years. The patients divided in to two groups such as positive control and Omega-3 Fatty Acid group. Each group contains 29 patients for evaluation of the parameters for four months follow-up for both control as well as Omega-3 Fatty Acid group, after 4 months of supplementation of Omega-3 Fatty Acid, it was found that, there is a significant decrease in values of microalbuminurea and HbA1c (Glycosylated haemoglobin) when compare to the positive control group. The result of study concludes that, the Omega-3 Fatty Acid significantly lowers urinary albumin excretion rate (UAER) and HbA1c in patients with diabetic nephropathy. So therefore supplementation of Omega -3 fatty acid may prevent the diabetic nephropathy
