Lipinski’s rule of five is widely used as a primary filter for screening compounds for their drug ability. In light of some literatures claiming the rules will not be fit to the natural products due to their complex structures, we have made an attempt to calculate some of the physicochemical properties such as LogP, percentage of human absorption, cLogP, hydrogen bond donors, hydrogen bond acceptors, number of aromatic rings, number of carbon atoms, volume, dipole, MR were calculated for the biologically active natural products. The results obtained reveal that they do fall under Lipinski’s rule of five. The results obtained are reported here along with the illustration using statistical plots.