Abstract

Introduction: Eclipta alba Hassk (Bhringaraj) grown widely in tropical countries, recently known to have diuretic and anti-hypertensive effect in the tribal community.

Objectives: Since the report has shown new dimension to one important clinical use and paucity of data available in this regard, the present work is undertaken to study the above mentioned effects in a scientific manner.

Materials & methods: Albino wistar rats (100-200gms) deprived of food for 15hrs divided into seven groups of six in each and put in metabolic cages after hydration by normal saline for 24hrs. Ethanolic extract of  Eclipta alba (EEEA) was administered in 50,100,200 and 400mg/kg doses per oral. Urinary volume, total Na⁺, K⁺, Cl^- concentration was  estimated at 5^th hr & 24^th hr and compared with control (saline treated) group. Furosemide (25mg/kg P.O) was taken as the standard.

Results: EEEA   was found to increase the urinary volume of the 5^th hr and 24^th hr sample in a dose dependent manner. Na⁺ & Cl^- excretion also significantly increased in 200&400 mg/kg doses. Synergistic Effect was not seen with furosemide.

Conclusion: EEEA was found to posse’s diuretic activity.

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