Abstract
More than half of the biologically active compounds produced by nature contain heterocyclic rings as fundamental components in their skeleton. These compounds and their modified products have popularly been utilized as pharmacophores for preparing drugs. 8-hydroxyquinoline has a wide variety of use and its medicinal and agricultural significance were discovered before the start of current century. Mannich reaction, o-alkylation and alkylation of 8-hydroxyquinoline resulted in very high yield of products. In the current publication we synthesized series of 8-hydroxy quinoline analogues which were prepared via Mannich based reaction. The synthesized analogues were characterized by 1HNMR, IR and Mass spectroscopy. The fungicidal and antibacterial properties are believed to be due to the chelation of essential trace metals on the surface of bacteria and fungi mainly by 8-hydroxyquinolines. Chelation of metals with 8-hydroxyquinoline is thought to facilitate the transport of metal across biological membrane. Analogues have been screened for their antibacterial and antifungal activity by the Disk diffusion method. Some of the analogues showed good activity against all the organisms. Biological data study shows synthesized compounds were had more antibiotic activity as compared to antifungal; particularly halo substituted aryl moiety may be responsible for the effective antibacterial activity.
