Abstract
A gold nanoparticle - modified glassy carbon electrode (AuNP/GCE) was prepared and its external morphology was characterised by scanning electron microscope (SEM) and surface area study. The electrochemical behaviour of tinidazole (TIN) at this electrode was examined by square wave voltammetry (SWV). At the AuNP/GCE, TIN exhibited a well-defined irreversible reduction peak at 548 mV in pH 3 acetate buffer solution whose potential is further reduced to 420 mV in the presence of an anionic surfactant sodium lauryl sulphate (NaLS). The effect of supporting electrolyte, number of cyclic scans for AuNP electro deposition and the effect of various surfactants were studied. The modified electrode showed good stability, selectivity and can be used to quantify TIN in a real pharmaceutical sample.
