Abstract
Different parts of the plant Averrhoa carambola L. is used for the treatment of various disease/disorder (s) by ethnic communities from North Maharashtra and Sonowal Kachari tribes of Dibrugarh, Assam. Still no scientific study is available about the hepatoprotective effect of the leaf of this plant. Present investigation aims to illustrate the hepatoprotective and antioxidant profile of leaves of Averrhoa carambola on carbon tetrachloride induced hepatic damage in mice. To achieve the objective, extracts were subjected to phytochemical screening. The leaf extract was then tested for its oral toxicity which was followed by evaluation of hepatoprotective and antioxidant activity at a dose level of 100mg/kg bw, 200mg/kg bw and 400mg/kg bw orally. Moreover, the hepatoprotective effect was further sustained by validating the leaf extract against different pharmacological parameters. Leaf extract of A.carambola possess phytoconstituents like alkaloids, tannins, reducing sugar and flavonoids. The extract did not any show any sign of toxicity. The pre-treatment of extract had significantly controlled the levels of serum biochemical and antioxidant enzymes. Finally the grades of hepatoprotectivity were further confirmed while experimenting against other parameters. Finally it can be concluded that the study demonstrates hepatoprotective and antioxidant activity of leaf of Averrhoa carambola and thus supports its usage in traditional medicine.
