Abstract

The present work has been designed to develop a simple manufacturing approach of torsemide loaded freeze-dried liposomes for intravenous administration to treat hepatic chirrosis and hypertension, possibly to minimize its side effect and pH related problems in blood. After reconstitution of the freeze dried formulation, it could be directly injected into the vein.  So to fulfill the objectives the torsemide loaded liposomes were formulated by Lipid film hydration technique using soya lecithin, cholesterol and drug in different weight ratios. The prepared liposomes were characterized in terms of drug excipient interaction by FTIR spectroscopy, morphological study of liposomes by using scanning electron microscopy (SEM), particle size and particle size distribution, polydispersity index, zeta potential, drug loading, drug release through dialysis membrane.