Abstract
From the very beginning of the human race; the quest is going on for newer and better alternatives. In the present study, bovine serum albumin (BSA) based microparticles bearing captopril were prepared by an emulsification–heat stabilization technique and emulsification polymerization technique. The prepared microparticles were studied for percentage practical yield, drug loading, particle size distribution, in vitro release characteristics and stability studies. Surface morphology was studied by scanning electron microscopy. Scanning electron microscopy of the microparticles revealed a spherical, nonporous and uniform appearance, with a smooth surface which prepared by heat stabilization method as compare to polymerization method. The microparticles had mean diameter between 2 and 12μm of which more than 75% were below 6μm and incorporation efficiency of 54.88–71.67%was obtained. In vitro release profile for formulations containing captopril-loaded albumin microparticles with heat stabilizing technique shows slow controlled release up to 24h against emulsification polymerization technique. On comparing regression-coefficient (r2) values for Hixson Crowel, Higuchi and Peppas kinetic models, different batches of microparticles showed Fickian, non-Fickian, & diffusion kinetics. Stability studies showed that maximum drug content and closest in vitro release to initial data were found in the formulation stored at 4˚C. Further research warranted on a modified formulation of captopril, is optimizing biodegradable microparticulate drug delivery system.
