Abstract

All the BCS Class-III drugs show high solubility and low permeability. Due to low permeability they have less intestinal absorption. The present study concentrates on the Metformin which is a BCS-III drug, which is having less permeability which in turn having less intestinal absorption. The permeability can be increased by using different permeation enhancers like chelates, salicylates, surfactants etc., The permeability of this drug was increased by the addition of sodium salicylate which acts as a permeation enhancer. This in turn results in better absorption enhancement. Six formulations were prepared in which calcium sulphate was used as filler and sodium salicylate as absorption enhancer where the amount of absorption enhancer increases from F1-F6 with the increment of 5mg for each formulation. All formulations are punched in the form of tablets with 350mg weight and this weight is kept common for all formulations. Out of all, F6 formulation shows highest absorption enhancement ratio. The absorption enhancement ratio was decided by the calculation of permeation coefficient by using everted sac method with simultaneous dissolution and absorption. The permeability studies were conducted ex vivo by using freshly scarified chicken intestine. This study revealed that 30 mg of sodium salicylate enhances intestinal absorption of 250 mg of Metformin.