Abstract

The purpose of the research was to develop and optimize the osmotic drug delivery system of Quetiapine fumarate, a schizophrenic drug using Design of Experiments. The Push-pull osmotic drug delivery system was selected as a suitable system since Push-pull osmotic drug delivery system is the preferred system for the highly insoluble drugs like quetiapine fumarate. Design Expert-8 from statease was used to study the impact of independent variables of core & coat of osmotic tablets in two different stages. The dependent variables selected were the dissolution at 24 hours and Zero order rate constant. The formulation development reveals that independent variables like Polyethylene oxide of drug layer and the push layer, sodium chloride of push layer and polyethylene glycol of the functional coating impacted the release profile at 24 hours of the osmotic drug delivery system. However the Zero order rate constant was not impacted by any of the independent variables.