Abstract
The present investigation was aimed at screening anticancer activity of ethanolic extract of sida acuta against NDEA and CCl4 induced hepatocellular cancers in wistar rats. A single dose of intraperitoneal injection of NDEA (200mg/kg b.wt) followed by CCl4 (3mg/kg) administration. The extent of liver damage was assessed by estimating the serum and tissue biochemical markers. The treatment with EESA at dose levels 200 and 400 mg/kg b.wt for 28 days significantly restored the elevated serum levels of SGOT, SGPT, ALP, LDH and GGT with prominent increase in protein synthesis in a dose dependent manner. The NDEA induced oxidative stress depleted the levels of antioxidant enzymes SOD and CAT with an increase in Lipid peroxidation. EESA showed a significant increase in activities of antioxidant enzymes that reduces the oxidative stress induced damage exhibiting a potent antioxidant and anticancer activity.
